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Technological Platforms

Molecular Imaging Facility

Radiochemistry

The radiochemistry platform includes a radiochemistry lab equipped with 5 hot cells which house automatic-remote controlled synthesis modules (suitable for the preparation of PET and SPECT radiotracers), a shielded laminar flow cabinet and state of the art quality control equipment, including radio-HPLC, radio-GC, radio-TLC and gamma spectrometry. The versatility of the equipments allows the synthesis of a wide range of known PET and SPECT radiotracers, as well as the design of new labelled structures to undertake pharmacokinetic and pharmacodynamic studies. The platform, furthermore, includes a fully equipped lab for radioactive metabolite analysis in blood and tissue samples and a cell culture lab for in vitro studies with radiolabelled ligands.

Person in charge

Vanessa Gómez Vallejo
  • Email: vgomez@cicbiomagune.es
  • Telephone no.: +34 943 00 53 30
  • Address: Parque tecnológico de San Sebastián
    Ed. Pº Miramón 182, Guipúzcoa
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Members

Mikel González Esparza

Technician

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Mikel Errasti López

Cyclotron Engineer

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Aitor Lekuona

Technician

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Publications

publications list

Biodistribution of Different Sized Nanoparticles Assessed by Positron Emission Tomography: A General Strategy for Direct Activation of Metal Oxide Particles. Pérez-Campaña C., Gómez-Vallejo V., Puigivila M., Martín A., Calvo-Fernández T., Moya S.E., Ziolo R.F., Reese T. and Llop J; 7 0, 3498-3505 (2013).


In vivo imaging of dopaminergic neurotransmission after transient focal ischemia in rats.. Martín A., Gómez-Vallejo V., San Sebastián E., Padró D., Makuerkiaga I., Llarena I. and Llop J; J. Cerebr. Blood F. Met 33, 244 - 252 (2013).


Biocompatible nanocomposite for PET/MRI hybrid imaging. Locatelli, E; Gil, L; Israel, L.L; Passoni, L; Naddaka, M; Pucci, A; Reese, T; Gomez-Vallejo, V; Milani, P; Mattioli, M; Llop, J; Lellouche, J.P; Franchini, M.C; Int. J. Nanomed. 7, 6021-6033 (2012).


Facile and improved synthesis of [11C]Me-QNB. Gomez-Vallejo, V; Gonzalez, M; Llop, J; J. Labelled Compd. Radiopharm. 55, 470-473 (2012).


Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation. Pérez-Campaña C., Gómez-Vallejo V., Martin A., San Sebasián E., Moya S.E., Reese T., Ziolo R.F. and Llop J; Analyst 137, 4902-4906 (2012).


Synthesis of 11C-labeled kendine-91, a histone deacetylase inhibitor. Aginagalde M., Gómez-Vallejo V., Vara Y., Cossio F. P. and Llop J.; Appl. Radiat. Isotopes. 70, 2552-2557 (2012).


Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats.. Gómez-Vallejo V., Martín A., Aginagalde M., San Sebastian E., Padro D., Cossio F.P. and Llop J.; Appl. Radiat. Isotopes. 70, 2545-2551 (2012).


Synthesis of novel pyrazole derivatives incorporating one dicarba-closo-dodecaborane unit.. Vázquez N., Gómez-Vallejo V. and Llop J.; Tetrahedron Letters 53, 4743-4746 (2012).


Synthesis of 13N-labelled radiotracers using microfluidic technology. Gaja V., Gómez-Vallejo V., Cuadrado M., Borrell J.I. and Llop J.; J. Labelled Compd. Rad. 55, 332-338 (2012).


Positron emission tomography with [13N]ammonia evidences long-term cerebral hyperperfusion after 2h-transient focal ischemia.. Martín A., San Sebastián E., Gómez-Vallejo V. and Llop J.; Neuroscience 213, 47-53 (2012).


Specific Activity of 11C-Labelled Radiotracers: A Big Challenge for PET Chemists. Gómez-Vallejo V., Gaja V., Koziorowski J. and Llop J.; Positron Emission Tomography - Current Clinical and Research Aspects 0, (2012).


Contribution of SPECT measurements of D2 and 5-HT2A occupancy to the clinical development of the antipsychotic SB-773812. Catafau, A.M; Bullich, S; Nucci, G; Burgess, C, et al; J. Nucl. Med. 52, 526-534 (2011).


Fully automated and reproducible radiosynthesis of high specific activity [11C]raclopride and [11C]Pittsburg compound-B using the combinations of two commercial synthesizers. Gómez-Vallejo V. and Llop J.; Nucl. Med. Commun. 32, 1011-1017 (2011).


Positron Emission Tomography with 11C-Flumazenil in the rat shows preservation of binding sites during the acute phase after 2H-Transient focal Ischemia. Rojas S, Martín A, Pareto D, Herance JR, Abad S., Ruíz A., Flotats N., Gispert J.D., Llop J., Gómez-Vallejo V., Planas A.M.; Neuroscience 182, 208-216 (2011).


Synthesis of D2 receptor ligands analogs incorporating one dicarba-closo-dodecaborane unit.. Vázquez N., Gómez-Vallejo V., Calvo J., Padro D. and Llop J.; Tetrahedron Lett 52, 615-618 (2011).


A convenient synthesis of 13N-labelled azo compounds: A new route for the preparation of amyloid imaging PET probes.. Gómez-Vallejo V., Borrell J.I., Llop J.; Eur. J. Med. Chem 45, 5318-5323 (2010).


Simultaneous Dual-tracer PET Imaging of the Rat Brain and its Application in the Study of Cerebral Ischemia.. Figueiras F.P, Jiménez X, Pareto D, Gómez V, Llop J, Herance R, Rojas S, Gispert J.D; Mol. Imag. Biol. 10, DOI: 10.1007/s11307-010-0370-5 (2010).


Fully automated synthesis of 13N-labeled nitrosothiols. Gómez-Vallejo V, Kato K, Oliden I, Calvo J, Baz Z, Borrell J.I, Llop J; Tetrahedron Letters 51, DOI: 10.1016/j.tetlet.2010.03.122 (2010).


Efficient system for the preparation of [13N]labeled nitrosamines. Gómez-Vallejo V, Kato K, Hanyu M, Minegishi K, Borrell JI, Llop J; Bioorg. med. Chem. Lett. 19, 1913-1915 (2009).


Depressed glucose consumption at reperfusion following brain ischemia does not correlate with mitochondrial dysfunction and development of infarction: an in vivo positron emission tomography study. Martín A, Rojas S, Pareto D, Santalucia T, Millán O, Abasolo I, Gómez V, Llop J, Gispert JD, Falcon C, Bargalló N, Planas AM; Current Neurovascular Research 6, 2 82-88 (2009).


Synthesis of S-[13N]Nitrosoglutathione (13N-GSNO) as a new potential PET imaging agent. Llop J, Gómez-Vallejo V, Bosque M, Quincoces G, Peñuelas I; Appl Radiat Isot 67, 95-99 (2009).


Specific activity of [11C]CH3I synthesized by the "wet" method: main sources of non-radioactive carbon. Gómez-Vallejo V, Llop J; Appl Radiat Isot 67, 111-114 (2009).


New Method for Routine Production of L-[Methyl]methionine: In Loop Synthesis. Gómez V, Amador V, Gispert JD, Llop J; J Label Compd Radiopharm 51, 1 83-86 (2008).


Imaging Brain Inflammation with [11C]PK11195 by PET and Induction of the Peripheral-Type Benzodiazepine Receptor after Transient Focal Ischemia in Rats. Rojas S, Martín A, Arranz MJ, Pareto D, Purroy J, Verdaguer E, Llop J, Gomez V, Gispert JD, Millan O, Chamorro A, Planas A; J Cereb Blood Flow Metab 27, 12 1975-1986 (2007).


Monitoring Gene Therapy by External Imaging mRNA: Pilot Study on Murine Erytropoietin. Segura J, Fillat C, Andreu D, Llop J, Millan O, de la Torre BG, Nikolovski Z, Gomez V, Andreu N, Pinyot A, Gispert JD, Pascual JA; Ther. Drug. Monit 29, 5 612-618 (2007).


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