In the last three decades in-vivo NMR methods, magnetic resonance imaging (MRI) and to some extent also spectroscopy (MRS), have been developed both for clinical applications and for experimental animal research. It is this link between clinical and preclinical applications which renders these methods attractive tools in pharmacological research. Special interest of the group is the utilization of optimized MR methods to relate pathophysiology with function in various animal models. Equipment: A 11.7Tesla 16 cm bore magnet, equipped with a 9cm shielded gradient capable of switching 600mT/m within 100us, can be used for studies. Based on its high sensitivity , five transmitters and 8 receivers are available for the development of novel parallel imaging protocols. Various radiofrequency-coils of different sizes enable sensitive setups to study morhophological, pathophysiological and functional alterations with MRI and/or MRS in small rodents.