Ermal Ismalaj

 

Ikerbasque and RyC Fellow at the Molecular and Functional Biomarkers Laboratory

Tel:+34 943 005 300. Ext 309

Ermal graduated in Pharmacy from the University of Siena and completed early research training at the University of Perugia (GreenSOC). He obtained his PhD in Organic Chemistry from the University of Lyon “Claude Bernard” in 2017, which included a short stay at the University of Oxford. He then joined KU Leuven as a postdoctoral researcher, first in the Department of Pharmaceutical and Pharmacological Sciences and later in the MolDesignS group as a Marie Curie–FWO fellow. During this period, he also carried out a research stay at CICbiomaGUNE.

In 2022, Ermal joined the Molecular and Functional Biomarkers group at CICbiomaGUNE led by Prof. Jesús Ruiz-Cabello as a Gipuzkoa Fellow Research Associate. He (co)directed 5 PhD and 5 Master’s theses, acted as (co)PI on several projects and as a PI on the AEI-funded project (SPARC).

His research expertise spans sustainable chemistry, organic synthesis, and biomedical imaging. His earlier works focused on greener routes for cross-coupling reactions, the development of bench-stable reagents in organofluorine chemistry, and sulfur–fluorine bond formation.

Currently, Ermal combines organic chemistry and molecular design to develop PET and fluorescent imaging agents for “untraceable” ion channels, with the final goal to define the role of these ion channels in diseases and their validation as potential biomarkers at preclinical level. Additionally, he is interested in developing novel synthetic methodologies for radioisotope tagging and in designing greener and more sustainable synthetic routes for accessing small molecules.

Outside the lab, Ermal is a proud father of two, enjoys hiking, cycles regularly (including commuting), and speaks six languages.

  • Scarponi, C; Cossio, FP; Ruiz-Cabello, J; Ismalaj, E. , Simplifying the access to FLYRCADO™: A shorter route for preparing [18F]flurpiridaz precursors under mild conditions Sustainable Chemistry and Pharmacy, 2026, 49, 102296
  • Piñol-Cancer, M; Fernández-Méndez, L; Carrillo-Romero, J; Urkola-Arsuaga, A; Azkargorta, M; Elortza, F; Goñi-de-Cerio, F; García-Mouton, C; de Alejo, CM; Ismalaj, E; Cañadas, O; Pérez-Gil, J; Ruíz-Cabello, J; Carregal-Romero, S. , The role of PEGylation in the pulmonary delivery of antifibrotic liposomal therapies J. Control. Release, 2025, 386, 114134
  • Ullah, K; Kordnezhadian, R; Demaerel, J; De Borggraeve, WM; Ismalaj, E. , Ex-situ ChloGen: A facile and straightforward entry to Aryl-IF4 compounds J. Fluor. Chem., 2024, 275, 110276
  • Fadon-Padilla, L; Miranda-Perez de Alejo, C; Miguel-Coello, AB; Beraza, M; Di Silvio, D; Urkola-Arsuaga, A; Sanchez-Guisado, MJ; Aiestaran-Zelaia, I; Fernandez-Mendez, L; Martinez-Parra, L; Ismalaj, E; Berra, E; Carregal-Romero, S; Ruiz-Cabello, J, Magnetic nanoradiotracers for targeted neutrophil detection in pulmonary arterial hypertension. J. Nanobiotechnology, 2024, 22, 709
  • Borgarelli, C; Klingl, YE; Escamilla-Ayala, A; Scarponi, C; La Rovere, RML; Dittlau, KS; Bultynck, G; Sampaolesi, M; Schoenberger, M; Munck, S; Van Den Bosch, L; De Borggraeve, WM; Ismalaj, E, Novel Far-Red Fluorescent 1,4-Dihydropyridines for L-Type Calcium Channel Imaging J. Med. Chem., 2024, 67, 18038-18052
  • Zogu, A; Ullah, K; Spanopoulos, S; Ismalaj, E; De Borggraeve, WM; Demaerel, J, Perfluorooxosulfate Salts as SOF4-Gas-Free Precursors to Multidimensional SuFEx Electrophiles Angew. Chem. Int. Ed., 2024, 63, e202403797
  • Kordnezhadian, R.; De Bels, T.; Su K.; Van Meervelt, L.; Ismalaj, E.; Demaerel, J; M. De Borggraeve, W.;, An Extrusion Strategy for On-Demand SF5Cl Gas Generation from a Commercial Disulfide Org. Lett., 2023, 25, 8947-8951
  • Kordnezhadian, R; Zogu, A; Borgarelli, C; Van Lommel, R; Demaerel, J; Ismalaj, E; De Borggraeve, W. , De-risking S–F bond formation: A gas cylinder-free strategy to access S(IV) and S(VI) fluorinated compounds. Chem. Eur. J., 2023, 29, e202300361
  • Li, B; Su, K; Van Meervelt, L; Verhelst, SHL; Ismalaj, E; De Borggraeve, WM; Demaerel, J. , Ex situ Generation of Thiazyl Trifluoride (NSF3) as a Gaseous SuFEx Hub Angew. Chem. Int. Ed., 2023, 62, e202305093
Funding Agency Call Identifier Acronym Title Project Code Start Date End Date Status
Ikerbasque Ikerbasque Research Fellows 2025 MoCa Novel molecular imaging tracers for cardiac diseases   2026-01-01 2031-01-01 Active
Spanish Research Agency - AEI Ayudas para contratos Ramón y Cajal (RYC 2024) MAST Novel Molecular imaging Agents for Studying transmembrane proteins RYC2024-048323-I 2025-12-01 2030-11-30 Active
CIC biomaGUNE 1st BREATH Call GaLu-Click-NSCLC A Pretargeted ⁶⁸Ga/¹⁷⁷Lu Click-Chemistry Platform for Safer and More Effective Lung Cancer Theranostics   2026-10-01 2028-09-30 Active
Spanish Research Agency - AEI Proyectos de Generación de Conocimiento (PID 2024) y actuaciones encaminadas a la formación de personal investigador predoctoral SPARC PET imaging agents for cardiovascular imaging PID2024-156747OA-I00 2025-09-01 2028-08-31 Active
Spanish Research Agency - AEI Acreditación R3 (antigua acreditación I3)   R3 acreditacion       Accepted
Basque Government Becas Ikasiker 2025-2026 NILE Novel imaging ligands for detecting epilepsy IkasC_2025_1_0074     Accepted

Niranjana Subrahmanian

PhD Student


Raquel Casares López

Postdoctoral Researcher