Malou Henriksen

 

Research Associate at the Bionanoplasmonics Laboratory

Dr. Malou Henriksen-Lacey gained her PhD from Aston University (Birmingham, UK) in 2011 in the field of liposomal vaccines under the supervision of Prof. Yvonne Perrie. She continued her postdoctoral research in nanoparticle vaccine delivery systems, later moving to the Bionanoplasmonics group led by Prof. Luis Liz-Marzán (CIC biomaGUNE). In 2017 she became a Research Associate in the same group, exploring various research lines including cancer and tissue engineering using bio-fabricated tissue models and advanced cellular imaging techniques.

She has published 57 peer-reviewed articles in internationally recognized journals and has over 4,000 citations. In addition, she has contributed to 2 book chapters and is inventor of 4 patents. Her findings have been presented in over 40 internal conferences. Currently she is co-PI of a nationally-funded grant and co-director of 3 PhD students.

Aside from her experimental research, Dr. Malou Henriksen-Lacey is interested in promoting sustainable actions in CICbiomaGUNE, leading the Sustainability Committee, and is a member of the works council.

  • Taleb, V; Sanz-Martinez, I; Serna, S; Bort-Grino, M; Narimatsu, Y; Furukawa, S; Reichardt, NC; Clausen, H; Merino, P; Hurtado-Guerrero, R, Plant fucosyltransferase FUT11 distorts the sugar acceptor to catalyze via a transient oxocarbenium intermediate mechanism. Nat. Commun., 2026, 17, 1960
  • Osterne, VJS; Ervijn, L; Oliveira, MV; Pinto-Junior, VR; Serna, S; Reichardt, NC; Nascimento, KS; Van Damme, EJM; Cavada, BS, Crystal structure, glycan specificity, and induction of cellular stress by the legume lectin DmegA. Int. J. Biol. Macromol., 2026, 358, 151795
  • Serna, S; Comino, N; Reichardt, NC; López-Gallego, F, Preparative Isolation of N-Glycans from Natural Sources Mediated by a Deglycosylating Heterogeneous Biocatalyst in Flow ChemSusChem, 2025, 18, e202402346
  • Alvarez, J; Parody, N; Calzada, D; Aranda, T; Renshaw, A; Serna, S; Reichardt, N; Beitia, JM; Gonzalez-de-Olano, D; Dominguez-Ortega, J; Carnes, J, Correlation Between N-Glycan GnGnXF3 and the Allergic Immune Response Against Juniperus ashei Pollen. Allergy, 2025, 80, 1935-1944
  • Navarro-Lleo, N; Ramirez-Cardenas, J; Paredes-Martinez, F; Serna, S; Gozalbo-Rovira, R; Munoz-Garcia, JC; Reichardt, NC; Casino, P; Angulo, J; Rodriguez-Diaz, J; Buesa, J, Interaction of the VP8* protein of a bovine rotavirus C with the H type-2 antigen and its precursor N-acetyl-lactosamine. Int. J. Biol. Macromol., 2025, 337, 149621
  • Osterne, VJS; Lima, LD; Oliveira, MV; Pinto-Junior, VR; Neto, CC; Correia, SEG; Suarez, C; Van Damme, EJM; Serna, S; Reichardt, NC; Nascimento, KS; Cavada, BS. , Novel Lectins from Bauhinia with Differential N-Glycan Binding Profiles ACS Omega, 2025, 10, 15637-15645
  • Nascimento, KS; Pinto-Junior, VR; Oliveira, MV; Osterne, VJS; Lossio, CF; Sacramento-Neto, JC; Ferreira, VMS; Silva-Leite, KES; Serna, S; Reichardt, N; Van Damme, E; Pires, AF; Cavada, BS; Assreuy, AMS, Novel LacdiNAc-specific lectin from Dioclea reflexa seeds exhibits inflammatory and hyper nociceptive properties. Int. J. Biol. Macromol., 2025, 309, 142868
  • Armero, L; Plou, J; Valera, PS; Serna, S; García, I; Liz-Marzán, LM., Multiplex Determination of Glycan Profiles on Urinary Prostate-Specific Antigen by Quartz-Crystal Microbalance Combined with Surface-Enhanced Raman Scattering ACS Sensors, 2024, 9, 4811-4821
  • Lossio, CF; Osterne, VJS; Pinto-Junior, VR; Chen, S; Oliveira, MV; Verduijn, J; Verbeke, I; Serna, S; Reichardt, NC; Skirtach, A; Cavada, BS; Van Damme, EJM; Nascimento, KS. , Structural Analysis and Characterization of an Antiproliferative Lectin from Canavalia villosa Seeds Int. J. Mol. Sci., 2023, 24, 15966
  • Krammer, E; Bridot, C; Serna, S; Echeverria, B; Semwal, S; Roubinet, B; van Noort, K; Wilbers, R; Bourenkov, G; de Ruyck, J; Landemarre, L; Reichardt, N; Bouckaert, J. , Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors J. Biol. Chem., 2023, 299, 104627
  • Zwanenburg, L; Borloo, J; Decorte, B; Bunte, MJM; Mokhtari, S; Serna, S; Reichardt, N; Seys, LJM; van Diepen, A; Schots, A; Wilbers, RHP; Hokke, CH; Claerebout, E; Geldhof, P. , Plant-based production of a protective vaccine antigen against the bovine parasitic nematode Ostertagia ostertagi Sci. Rep., 2023, 13, 20488
  • Serna, S; Artschwager, R; Pérez-Martínez, D; Lopez, R; Reichardt, N. , Versatile Urea Type Linker For Functionalisation of Natural Glycans and its Validation in Glycan Arrays Chem. Eur. J., 2023, 29, e202301494
  • Osterne, VJS; Oliveira, MV; De Schutter, K; Serna, S; Reichardt, NC; Smagghe, G; Cavada, BS; Van Damme, EJM; Nascimento, KS, A galactoside-specific Dalbergieae legume lectin from seeds of Vataireopsis araroba (Aguiar) Ducke Glycoconjugate J., 2022, 40, 85-95
  • Bertuzzi, S; Peccati, F; Serna, S; Artschwager, R; Notova, S; Thépaut, M; Jiménez-Osés, G; Fieschi, F; Reichardt, NC; Jiménez-Barbero, J; Ardá, A. , Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin ACS Cent. Sci., 2022, 8, 1415-1423
  • Sucre, A; Amaya-Rodriguez, I; Rho, H; Serna, S; Reichardt, N; Garin-Muga, A; Epelde, G. , COVID-BIOCHIP: A Web Tool to Analyse COVID-19 Antigen Microarrays Stud. Health Technol. Inform., 2022, 295, 183 - 186
  • Huettner, I; Krumm, SA; Serna, S; Brzezicka, K; Monaco, S; Walpole, S; van Diepen, A; Allan, F; Hicks, T; Kimuda, S; Emery, AM; Landais, E; Hokke, CH; Angulo, J; Reichardt, N; Doores, KJ, Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans Cell. Rep., 2022, 38, 110611
  • García-García, A; Serna, S; Yang, Z; Delso, I; Taleb, V; Hicks, T; Artschwager, R; Vakhrushev, SY; Clausen, H; Angulo, J; Corzana, F; Reichardt, NC; Hurtado-Guerrero, R. , FUT8-Directed Core Fucosylation of N-glycans Is Regulated by the Glycan Structure and Protein Environment ACS Catal., 2021, 11, 9052-9065
  • Nkurunungi, G; Mpairwe, H; Versteeg, SA; Diepen, A; Nassuuna, J; Kabagenyi, J; Nambuya, I; Sanya, RE; Nampijja, M; Serna, S; Reichardt, N; Hokke, CH; Webb, EL; Ree, R; Yazdanbakhsh, M; Elliott, AM. , Cross-reactive carbohydrate determinant-specific IgE obscures true atopy and exhibits alpha-1,3-fucose epitope-specific inverse associations with asthma Allergy, 2021, 76, 233-246
  • Chen, PY; De Schutter, K; Serna, S; Chen, SM; Yang, Q; Reichardt, NC; Van Damme, EJM; Smagghe, G, Glycosylation reduces the glycan-independent immunomodulatory effect of recombinant Orysata lectin in Drosophila S2 cells Sci. Rep., 2021, 11, 17958
  • Oliveira, MV; Osterne, VJS; Lossio, CF; Serna, S; Reichardt, NC; Nascimento, KS; Van Damme, EJM; Cavada, BS, Purification and characterization of a highly thermostable GlcNAc-binding lectin from Collaea speciosa seeds Int. J. Biol. Macromol., 2021, 193, 1562-1571
  • Huettner, I; Krumm, S; Landais, E; Brzezicka, K; Serna, S; van Diepen, A; Angulo, J; Allan, F; Emery, A; Reichardt, N; Hokke, R; Poignard, P; Doores, K, Cross-reactivity between HIV-1 bnAbs and parasite glycans J. Int. AIDS Soc., 2021, 24, 41
  • Robakiewicz, S; Bridot, C; Serna, S; Gimeno, A; Echeverria, B; Delgado, S; Ruyck, J; Semwal, S; Charro, D; Dansercoer, A; Verstraete, K; Azkargorta, M; Noort, K; Wilbers, R; Savvides, SN; Abrescia, NGA; Arda, A; Reichardt, NC; Jiménez-Barbero, J; Bouckaert, J. , Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins Glycobiology, 2021, 31, 1005-1017
  • Heidepriem, J; Dahlke, C; Kobbe, R; Santer, R; Koch, T; Fathi, A; Seco, B; Ly, M; Schmiedel, S; Schwinge, D; Serna, S; Sellrie, K; Reichardt, N; Seeberger, P; Addo, M; Loeffler, F; . , Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series Pathogens, 2021, 10, 438
  • Nkurunungi, G; van Diepen, A; Nassuuna, J; Sanya, RE; Nampijja, M; Nambuya, I; Kabagenyi, J; Serna, S; Reichardt, N; van Ree, R; Webb, EL; Elliott, AM; Yazdanbakhsh, M; Hokke, CH. , Microarray assessment of N-glycan-specific IgE and IgG profiles associated with Schistosoma mansoni infection in rural and urban Uganda Sci. Rep., 2019, 9, 3522
  • Echeverria, B; Serna, S; Achilli, S; Vives, C; Pham, J; Thepaut, M; Hokke, CH; Fieschi, F; Reichardt, NC, Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors ACS Chem. Biol., 2018, 13, 2269-2279
  • Brzezicka, KA; Serna, S; Reichardt, NC. , Fluorescent Neoglycoprotein Gold Nanoclusters: Synthesis and Applications in Plant Lectin Sensing and Cell Imaging Nanoscale Res. Lett., 2018, 13, 360
  • Serna, S; Ercibengoa, M; Marimón, JM; Reichardt, N. , Measuring Bacterial Glycosyl Hydrolase Activity with a Soluble Capture Probe by Mass Spectrometry Anal. Chem., 2018, 90, 12536-12543
  • Medve, L; Achilli, S; Serna, S; Zuccotto, F; Varga, N; Thépaut, M; Civera, M; Vivès, C; Fieschi, F; Reichardt, N; Bernardi, A. , On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin Chem. Eur. J., 2018, 24, 14448-14460
  • Unione, L; Alcalá, M; Echeverria, B; Serna, S; Ardá, A; Franconetti, A; Cañada, FJ; Diercks, T; Reichardt, N; Jiménez-Barbero, J. , Fluoroacetamide Moieties as NMR Probes for molecular recognition of GlcNAc-containing sugars: Modulation of the CH-π Stacking Interactions by Different Fluorination Patterns Chem. Eur. J., 2017, 23, 3957-3965
  • Lang, V; Aillet, F; Xolalpa, W; Serna, S; Ceccato, L; Lopez-Reyes, RG; Lopez-Mato, MP; Januchowski, R; Reichardt, N; Rodriguez, MS. , Analysis of defective protein ubiquitylation associated to adriamycin resistant cells Cell Cycle, 2017, 16, 2337-2344
Funding Agency Call Identifier Acronym Title Project Code Start Date End Date Status
Basque Foundation for Health Innovation and Research (BIOEF) Proyectos de investigación en cáncer de BIOEF-EITB Maratoia 2024 MIOCART Enfoque multiómico y espectroscópico integrado mediante análisis de aprendizaje automático para la identificación de nuevos biomarcadores CAR-T en sangre de pacientes con mieloma múltiple BIO24/CA/008 2025-05-01 2028-04-30 Active
Basque Government Ayudas a proyectos de investigación y desarrollo en salud (RIS3) 2025 BIOCART(3) Enfoque multiómico y espectroscópico integrado para la identificación de nuevos biomarcadores CAR-T en sangre mediante análisis de aprendizaje automático 2025333033 2025-01-01 2025-12-31 Finalised