Sonia Serna

 

Research Associate at the Glycotechnology Laboratory

Tel:+34 943 00 53 19

Dr. Sonia Serna obtained her PhD in Organic Chemistry in 2005 from the University of the Basque Country (EHU) under the supervision of Prof Dr Esther Domínguez Pérez with a dissertation focused on developing new synthetic methodologies using hypervalent iodine reagents.

During her doctoral studies, she did a research stay in the group of Prof. Dr Erick M. Carreira at the Swiss Federal Institute of Technology (ETH-Zürich), working on the design and preparation of novel chiral ligands for asymmetric catalysis. After her doctoral studies, she worked as a researcher at Planta Piloto de Química Fina (University of Alcalá), synthesising and scaling up active pharmaceutical ingredients for pharma companies.

In 2007, she joined the laboratory of Prof. Manuel Martín-Lomas and Dr. Niels Reichardt at CIC biomaGUNE as a postdoctoral researcher, where she currently continues as a research associate.

Her current research focusses on studying the role of carbohydrates in biological systems, utilising a combination of chemical synthesis, enzymatic modifications, and mass spectrometry. She is responsible for the microarray equipment of CICbiomaGUNE, which produces carbohydrate and protein microarrays that are then used in basic research to study protein-carbohydrate interactions as well as in the study of biomarkers for various pathologies such as cancer, AIDS, allergies, and bacterial infections.

  • Osterne, VJS; Lima, LD; Oliveira, MV; Pinto-Junior, VR; Neto, CC; Correia, SEG; Suarez, C; Van Damme, EJM; Serna, S; Reichardt, NC; Nascimento, KS; Cavada, BS. , Novel Lectins from Bauhinia with Differential N-Glycan Binding Profiles ACS Omega, 2025, In press
  • Nascimento, KS; Pinto-Junior, VR; Oliveira, MV; Osterne, VJS; Lossio, CF; Sacramento-Neto, JC; Ferreira, VMS; Silva-Leite, KES; Serna, S; Reichardt, N; Van Damme, E; Pires, AF; Cavada, BS; Assreuy, AMS, Novel LacdiNAc-specific lectin from Dioclea reflexa seeds exhibits inflammatory and hyper nociceptive properties. Int. J. Biol. Macromol., 2025, 309, 142868
  • Serna, S; Comino, N; Reichardt, NC; López-Gallego, F, Preparative Isolation of N-Glycans from Natural Sources Mediated by a Deglycosylating Heterogeneous Biocatalyst in Flow ChemSusChem, 2025, In press
  • Alvarez, J; Parody, N; Calzada, D; Aranda, T; Renshaw, A; Serna, S; Reichardt, N; Beitia, JM; Gonzalez-de-Olano, D; Dominguez-Ortega, J; Carnes, J, Correlation Between N-Glycan GnGnXF3 and the Allergic Immune Response Against Juniperus ashei Pollen. Allergy, 2025, In press
  • Armero, L; Plou, J; Valera, PS; Serna, S; García, I; Liz-Marzán, LM., Multiplex Determination of Glycan Profiles on Urinary Prostate-Specific Antigen by Quartz-Crystal Microbalance Combined with Surface-Enhanced Raman Scattering ACS Sensors, 2024, 9, 4811-4821
  • Lossio, CF; Osterne, VJS; Pinto-Junior, VR; Chen, S; Oliveira, MV; Verduijn, J; Verbeke, I; Serna, S; Reichardt, NC; Skirtach, A; Cavada, BS; Van Damme, EJM; Nascimento, KS. , Structural Analysis and Characterization of an Antiproliferative Lectin from Canavalia villosa Seeds Int. J. Mol. Sci., 2023, 24, 15966
  • Krammer, E; Bridot, C; Serna, S; Echeverria, B; Semwal, S; Roubinet, B; van Noort, K; Wilbers, R; Bourenkov, G; de Ruyck, J; Landemarre, L; Reichardt, N; Bouckaert, J. , Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors J. Biol. Chem., 2023, 299, 104627
  • Zwanenburg, L; Borloo, J; Decorte, B; Bunte, MJM; Mokhtari, S; Serna, S; Reichardt, N; Seys, LJM; van Diepen, A; Schots, A; Wilbers, RHP; Hokke, CH; Claerebout, E; Geldhof, P. , Plant-based production of a protective vaccine antigen against the bovine parasitic nematode Ostertagia ostertagi Sci. Rep., 2023, 13, 20488
  • Serna, S; Artschwager, R; Pérez-Martínez, D; Lopez, R; Reichardt, N. , Versatile Urea Type Linker For Functionalisation of Natural Glycans and its Validation in Glycan Arrays Chem. Eur. J., 2023, 29, e202301494
  • Osterne, VJS; Oliveira, MV; De Schutter, K; Serna, S; Reichardt, NC; Smagghe, G; Cavada, BS; Van Damme, EJM; Nascimento, KS, A galactoside-specific Dalbergieae legume lectin from seeds of Vataireopsis araroba (Aguiar) Ducke Glycoconjugate J., 2022, 40, 85-95
  • Bertuzzi, S; Peccati, F; Serna, S; Artschwager, R; Notova, S; Thépaut, M; Jiménez-Osés, G; Fieschi, F; Reichardt, NC; Jiménez-Barbero, J; Ardá, A. , Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin ACS Cent. Sci., 2022, 8, 1415-1423
  • Sucre, A; Amaya-Rodriguez, I; Rho, H; Serna, S; Reichardt, N; Garin-Muga, A; Epelde, G. , COVID-BIOCHIP: A Web Tool to Analyse COVID-19 Antigen Microarrays Stud. Health Technol. Inform., 2022, 295, 183 - 186
  • Huettner, I; Krumm, SA; Serna, S; Brzezicka, K; Monaco, S; Walpole, S; van Diepen, A; Allan, F; Hicks, T; Kimuda, S; Emery, AM; Landais, E; Hokke, CH; Angulo, J; Reichardt, N; Doores, KJ, Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans Cell. Rep., 2022, 38, 110611
  • Nkurunungi, G; Mpairwe, H; Versteeg, SA; Diepen, A; Nassuuna, J; Kabagenyi, J; Nambuya, I; Sanya, RE; Nampijja, M; Serna, S; Reichardt, N; Hokke, CH; Webb, EL; Ree, R; Yazdanbakhsh, M; Elliott, AM. , Cross-reactive carbohydrate determinant-specific IgE obscures true atopy and exhibits alpha-1,3-fucose epitope-specific inverse associations with asthma Allergy, 2021, 76, 233-246
  • Chen, PY; De Schutter, K; Serna, S; Chen, SM; Yang, Q; Reichardt, NC; Van Damme, EJM; Smagghe, G, Glycosylation reduces the glycan-independent immunomodulatory effect of recombinant Orysata lectin in Drosophila S2 cells Sci. Rep., 2021, 11, 17958
  • Oliveira, MV; Osterne, VJS; Lossio, CF; Serna, S; Reichardt, NC; Nascimento, KS; Van Damme, EJM; Cavada, BS, Purification and characterization of a highly thermostable GlcNAc-binding lectin from Collaea speciosa seeds Int. J. Biol. Macromol., 2021, 193, 1562-1571
  • Huettner, I; Krumm, S; Landais, E; Brzezicka, K; Serna, S; van Diepen, A; Angulo, J; Allan, F; Emery, A; Reichardt, N; Hokke, R; Poignard, P; Doores, K, Cross-reactivity between HIV-1 bnAbs and parasite glycans J. Int. AIDS Soc., 2021, 24, 41
  • Robakiewicz, S; Bridot, C; Serna, S; Gimeno, A; Echeverria, B; Delgado, S; Ruyck, J; Semwal, S; Charro, D; Dansercoer, A; Verstraete, K; Azkargorta, M; Noort, K; Wilbers, R; Savvides, SN; Abrescia, NGA; Arda, A; Reichardt, NC; Jiménez-Barbero, J; Bouckaert, J. , Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins Glycobiology, 2021, 31, 1005-1017
  • Heidepriem, J; Dahlke, C; Kobbe, R; Santer, R; Koch, T; Fathi, A; Seco, B; Ly, M; Schmiedel, S; Schwinge, D; Serna, S; Sellrie, K; Reichardt, N; Seeberger, P; Addo, M; Loeffler, F; . , Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series Pathogens, 2021, 10, 438
  • García-García, A; Serna, S; Yang, Z; Delso, I; Taleb, V; Hicks, T; Artschwager, R; Vakhrushev, SY; Clausen, H; Angulo, J; Corzana, F; Reichardt, NC; Hurtado-Guerrero, R. , FUT8-Directed Core Fucosylation of N-glycans Is Regulated by the Glycan Structure and Protein Environment ACS Catal., 2021, 11, 9052-9065
  • Nkurunungi, G; van Diepen, A; Nassuuna, J; Sanya, RE; Nampijja, M; Nambuya, I; Kabagenyi, J; Serna, S; Reichardt, N; van Ree, R; Webb, EL; Elliott, AM; Yazdanbakhsh, M; Hokke, CH. , Microarray assessment of N-glycan-specific IgE and IgG profiles associated with Schistosoma mansoni infection in rural and urban Uganda Sci. Rep., 2019, 9, 3522
  • Brzezicka, KA; Serna, S; Reichardt, NC. , Fluorescent Neoglycoprotein Gold Nanoclusters: Synthesis and Applications in Plant Lectin Sensing and Cell Imaging Nanoscale Res. Lett., 2018, 13, 360
  • Serna, S; Ercibengoa, M; Marimón, JM; Reichardt, N. , Measuring Bacterial Glycosyl Hydrolase Activity with a Soluble Capture Probe by Mass Spectrometry Anal. Chem., 2018, 90, 12536-12543
  • Medve, L; Achilli, S; Serna, S; Zuccotto, F; Varga, N; Thépaut, M; Civera, M; Vivès, C; Fieschi, F; Reichardt, N; Bernardi, A. , On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin Chem. Eur. J., 2018, 24, 14448-14460
  • Echeverria, B; Serna, S; Achilli, S; Vives, C; Pham, J; Thepaut, M; Hokke, CH; Fieschi, F; Reichardt, NC, Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors ACS Chem. Biol., 2018, 13, 2269-2279
  • Unione, L; Alcalá, M; Echeverria, B; Serna, S; Ardá, A; Franconetti, A; Cañada, FJ; Diercks, T; Reichardt, N; Jiménez-Barbero, J. , Fluoroacetamide Moieties as NMR Probes for molecular recognition of GlcNAc-containing sugars: Modulation of the CH-π Stacking Interactions by Different Fluorination Patterns Chem. Eur. J., 2017, 23, 3957-3965
  • Lang, V; Aillet, F; Xolalpa, W; Serna, S; Ceccato, L; Lopez-Reyes, RG; Lopez-Mato, MP; Januchowski, R; Reichardt, N; Rodriguez, MS. , Analysis of defective protein ubiquitylation associated to adriamycin resistant cells Cell Cycle, 2017, 16, 2337-2344
Funding Agency Call Identifier Acronym Title Project Code Start Date End Date Status
Basque Foundation for Health Innovation and Research (BIOEF) Proyectos de investigación en cáncer de BIOEF-EITB Maratoia 2024 MIOCART Enfoque multiómico y espectroscópico integrado mediante análisis de aprendizaje automático para la identificación de nuevos biomarcadores CAR-T en sangre de pacientes con mieloma múltiple BIO24/CA/008 2025-05-01 2028-04-30 Active