Intelligent nanoengineering is transforming nanomedicine by enabling the rational design of nanomaterials that actively sense, respond, and adapt to complex biological environments. This talk will present recent advances from Dr. Xiaohui Ju’s research program, focusing on intelligent nanomaterials and nanorobotic systems engineered at the atomic, nanoscale, and colloidal levels for biomedical applications. Key topics include enzyme-mimetic cerium-based nanomaterials for redox regulation, single-atom nanozymes with enhanced catalytic precision, and chemically or magnetically powered nanorobots capable of controlled motion, transvascular navigation, and targeted therapeutic action. By integrating nanoengineering, biophysics, and biomedical validation, this work demonstrates how intelligent nanorobots can overcome current limitations in delivery, efficacy, and safety, paving the way toward next-generation nanomedicine for regenerative therapy, vascular repair, and precision antioxidant treatment.