Schizophrenia is a complex brain disorder that affects perception, cognition, and behavior, and understanding its biological origins remains a major challenge. The 22q11.2 deletion syndrome is one of the strongest known genetic risk factors for developing schizophrenia and offers a unique opportunity to study early brain changes related to the disease. In this work, we combined PET and MRI to investigate how brain structure and dopamine function evolve over time in a mouse model of 22q11.2 deletion. This approach provides new insights into the neurobiological mechanisms underlying vulnerability to schizophrenia.